2025 Frontier Mpg. Epa mpg owner mpg estimates 2025 nissan frontier 2wd 6 cyl, 3.8 l, automatic (s9) regular gasoline In its most efficient configuration, the frontier can get up to 21 mpg combined (18 mpg in the city and 24 mpg on the highway).

These figures lag behind trucks. 1984 to present buyer’s guide to fuel.